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Breast cancer with BRCA mutations four times more likely to have a contralateral breast cancer
Women with breast cancer before the age of 55 who have a mutation in the genes inherited breast cancer susceptibility BRCA1 or BRCA2 genes are four times more likely to develop breast cancer in the forehead, or contralateral their initial tumor compared to breast cancer patients without these genetic defects. These results, Fred Hutchinson Cancer Research Center Breast Cancer Epidemiologist Kathleen Malone, Ph.D., and colleagues, were published online April 5 in the Journal of Clinical Oncology.
Compared with noncarriers, the breast cancer patients with BRCA1 mutation have a risk 4.5 times higher and those with a BRCA2 mutation have a 3.4 times greater risk of subsequent breast cancer, researchers have found. Carriers of both mutations who were diagnosed with breast cancer before 55 compared to 18 per cent chance of developing cancer is cumulative in the opposite breast within 10 years, compared with a cumulative probability of 5 percent among women who had no mutation.