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Synthetic peptide can improve lung transplantation
Lung transplant patients may benefit from a day of a synthetic peptide that mimics the body’s natural ability to reduce the excessive accumulation of fluid, Medical College of Georgia researchers report.Excess fluid and other problems that can occur within 72 hours of a transplant can significantly reduce short-term survival and long-term lung function. About 10 percent of patients with acute lung injury in the first hours after transplantation, killing more than 40 percent of these patients within 30 days.
MCG researchers have shown in the March issue of Critical Care Medicine that the release of peptide TIP trachea in the lungs of rats in a half hour before surgery can remove the bad result, known as ischemic reperfusion injury and improve oxygenation.
“We see that the parameters of lung transplantation are almost normal,” said Dr. Rudolf Lucas, a biologist in the MCG Vascular Biology Center for Vascular and author of the paper.