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Drug reduces risk of prostate cancer diagnosed in men at high risk
A drug already prescribed to reduce benign prostatic hypertrophy has been shown to reduce the risk of a diagnosis of prostate cancer by 23 percent in men at high risk of disease, a major international study has found. The results are presented on 1 April in the New England Journal of Medicine.The four-year study has found that dutasteride (Avodart ®) significantly reduced the likelihood that men will be diagnosed with tumors that are most often treated as too: those who fall in the middle range of aggressiveness. These tumors, which represent the majority of all prostate cancers, grow in unpredictable ways. This uncertainty has led many men to choose surgery or radiation therapy – treatments that can lead to incontinence and impotence.
“The dutasteride can potentially provide thousands of men one way to reduce the risk of being diagnosed with prostate cancer,” says study author Gerald Andrioli, MD, Robert Killian Royce, MD, Professor Emeritus and Head of Urology at the University of Washington School of Medicine in St. Louis. “This means more men can avoid unnecessary treatment for prostate cancer, as well as the costs and negative side effects that may occur with treatment.”
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Increased risk of diabetes for mothers who do not breastfeed
New research shows having children increases the chances of a woman with type 2 diabetes, but breastfeeding can reduce the risk to the same level as women who never had children.
The study, published in the American Diabetes Association’s journal Diabetes Care, compared with women with similar weight and examined the effect on type 2 diabetes have had children and had breastfed. Data were drawn from Australia’s largest study of healthy aging – 45 years – and the study was co-written by Professor Emily Banks, the National Center for Epidemiology and Population Health at the National University of Australia.
Study author Dr. Bette Liu said, women who are not breastfed were 50% more likely to develop diabetes later in life compared with women who had no children.
“But women who had children, and within each child at least three months had no increased risk of developing diabetes,” says Dr. Liu.
Nerve growth factor decreases death after a heart attack
Nerve growth factor (NGF) has improved the functioning of the heart muscle damaged by a new study in mice – a discovery that could provide a new treatment for humans, researchers report in the journal Circulation Research, a journal of the American Heart Association .
NGF is a small protein important for the survival of certain nerve cells. However, recent studies indicate that NGF is important for a variety of body processes nerves beyond help.
The study is the first to explore the role of NGF in the heart of the cell in health and healing rather than its influence on cardiac nerves.
“It’s the last survey indicated that factors affecting growth over the body part for which you are appointed,” said Costanza Emanueli, PhD, lead study author, a reader (associate professor) University of Bristol in England and a member British Heart Foundation Senior Research. “The most significant finding was that NGF gene therapy improved survival suffered a heart attack.”