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Peritoneal mesothelioma
Malignant peritoneal mesothelioma is a rare form of cancer that develops in the thin cell walls that surround the abdominal cavity, called the peritoneum. Other types of cancer, including mesothelioma malignant pleural mesothelioma, which occurs in the cell wall that surrounds the lungs and malignant pericardial mesothelioma, which occurs in the pericardial wall of the house. peritoneal mesothelioma is the rarest form, the second of the disease and accounts for approximately 20% of cases of mesothelioma each year.
What causes peritoneal mesothelioma?
Peritoneal mesothelioma is known to be caused by exposure to asbestos. Asbestos is said to reach the abdominal wall by one of two methods. The first is through the ingestion of asbestos fibers that are processed by digestion and stay in the peritoneum. The other method is through the lungs and lymph nodes by inhaled asbestos fibers. Malignant pleural mesothelioma is also known to metastasize directly into the abdominal cavity, if disclosure is not slower.
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Further research is promising cancer treatment
A protein that functions as a cancer drug for leadership in animal experiments has been developed by an international team that includes several researchers from the University of Western Australia.
The natural protein is known to play an important role in promoting cell death (for example in mammary cells after the young are weaned), prevention of cell proliferation, promoting cell differentiation, and in this new discovery, by blocking the formation of blood vessels.
The trial results, published in the American Journal of Pathology showed that the protein – related protein secreted curly 4 (sFRP4) – inhibits tumors in the same degree as a very successful antibody, Avastin ®.
Winthrop Professor Arun Dharmaraj UWA School of Anatomy and Human Biology and UWA, said Anna University (AU), Chennai, India, holders of patents on the use of sFRP4 as angiogenesis inhibitor and are eager to find a trading partner for project.
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Treatment resistance of some cancer cells may be reversible
The ability of cancer cells resistant to treatment with targeted therapies or conventional chemotherapy in some cases, the result of a transient state of reversible drug “tolerance.” In an article published in the April 2 issue of Cell, researchers from Massachusetts General Hospital (MGH) Cancer Center announce the presence of small populations of drug-tolerant cells of various types of tumors and identify aspects of the underlying mechanism.
“Despite resistance to anticancer drugs may result from preexisting rare genetic mutations that occur in response to treatment, the accumulation of evidence has done in other non-genetic mechanisms of potentially irreversible,” said Jeffrey Settleman, PhD , of the MGH Cancer Center, who led the study. “In cell lines derived from different types of cancer are subpopulations of cells that display an ability to transition to tolerate exposure to toxic drugs, which has been associated with structural changes in the DNA of cells and suggests a therapeutic strategy that could prevent developing resistance. ”